1683-1683
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ANNOUNCEMENTS
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COMMUNICATIONS TO THE EDITOR
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1684-1686
| 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]- phenol Hydrochloride (SIB-1553A): A Novel Cognitive Enhancer with Selectivity for Neuronal Nicotinic Acetylcholine Receptors
Jean-Michel Vernier,
Hassan El-Abdellaoui,
Heather Holsenback,
Nicholas D. P. Cosford,
Leo Bleicher,
Geoffrey Barker,
Bruno Bontempi,
Laura Chavez-Noriega,
Frederique Menzaghi,
Tadimeti S. Rao,
Richard Reid,
Aida I. Sacaan,
Carla Suto,
Mark Washburn,
G. Kenneth Lloyd, and
Ian A. McDonald
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ARTICLES
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1687-1697
| Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance: Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range
Elisabetta Teodori,
Silvia Dei,
Patricia Quidu,
Roberta Budriesi,
Alberto Chiarini,
Arlette Garnier-Suillerot,
Fulvio Gualtieri,
Dina Manetti,
Maria Novella Romanelli, and
Serena Scapecchi
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1698-1704
| Novel Arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-Dioxides as Inhibitors of Platelet Aggregation. 1. Synthesis and Pharmacological Evaluation
Nuria Campillo,
Concepción García,
Pilar Goya,
Juan A. Páez,
Emilio Carrasco, and
Manuel Grau
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1705-1713
| Solution Conformation of a Potent Cyclic Analogue of Tuftsin: Low- Temperature Nuclear Magnetic Resonance Study in a Cryoprotective Mixture
Annamaria D'Ursi,
Stefania Albrizio,
Caterina Fattorusso,
Antonio Lavecchia,
Giancarlo Zanotti, and
Piero A. Temussi
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1714-1722
| An Effort To Understand the Molecular Basis of Hypertension through the Study of Conformational Analysis of Losartan and Sarmesin Using a Combination of Nuclear Magnetic Resonance Spectroscopy and Theoretical Calculations
Thomas Mavromoustakos,
Antonios Kolocouris,
Maria Zervou,
Panagiota Roumelioti,
John Matsoukas, and
Rudiger Weisemann
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1723-1738
| Homology Modeling of Gelatinase Catalytic Domains and Docking Simulations of Novel Sulfonamide Inhibitors
Ryuichi Kiyama,
Yoshinori Tamura,
Fumihiko Watanabe,
Hiroshige Tsuzuki,
Mitsuaki Ohtani, and
Mitsuaki Yodo
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1739-1748
| Molecular Hashkeys: A Novel Method for Molecular Characterization and Its Application for Predicting Important Pharmaceutical Properties of Molecules
Anwar M. Ghuloum,
Carleton R. Sage, and
Ajay N. Jain
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1749-1756
| Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors
Gary Phillips,
David D. Davey,
Keith A. Eagen,
Sunil K. Koovakkat,
Amy Liang,
Howard P. Ng,
Michael Pinkerton,
Lan Trinh,
Marc Whitlow,
Alicia M. Beatty, and
Michael M. Morrissey
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1757-1766
| Ligands for the Tyrosine Kinase p56lck SH2 Domain: Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements
Pierre L. Beaulieu,
Dale R. Cameron,
Jean-Marie Ferland,
Jean Gauthier,
Elise Ghiro,
James Gillard,
Vida Gorys,
Martin Poirier,
Jean Rancourt,
Dominik Wernic, and
Montse Llinas-Brunet
, Raj Betageri,
Mario Cardozo,
Eugene R. Hickey,
Richard Ingraham,
Scott Jakes,
Alisa Kabcenell,
Tom Kirrane,
Susan Lukas,
Usha Patel,
John Proudfoot,
Rajiv Sharma,
Liang Tong, and
Neil Moss
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1767-1777
| Extension of the Polyanionic Cosalane Pharmacophore as a Strategy for Increasing Anti-HIV Potency
Mark Cushman,
Shabana Insaf,
Gitendra Paul,
Jeffrey A. Ruell,
Erik De Clercq,
Dominique Schols,
Christophe Pannecouque,
Myriam Witvrouw,
Catherine A. Schaeffer,
Jim A. Turpin,
Karen Williamson, and
William G. Rice
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1778-1788
| The Role of Waters in Docking Strategies with Incremental Flexibility for Carbohydrate Derivatives: Heat-Labile Enterotoxin, a Multivalent Test Case
Wendy E. Minke,
David J. Diller,
Wim G. J. Hol, and
Christophe L. M. J. Verlinde
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1789-1802
| Structure-Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine
Tsutomu Mimoto,
Ryohei Kato,
Haruo Takaku,
Satoshi Nojima,
Keisuke Terashima,
Satoru Misawa,
Tominaga Fukazawa,
Takamasa Ueno,
Hideharu Sato,
Makoto Shintani,
Yoshiaki Kiso, and
Hideya Hayashi
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1803-1815
| Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor
Jeff B. Smaill,
Brian D. Palmer,
Gordon W. Rewcastle,
William A. Denny,
Dennis J. McNamara,
Ellen M. Dobrusin,
Alexander J. Bridges,
Hairong Zhou,
H. D. Hollis Showalter,
R. Thomas Winters,
Wilbur R. Leopold,
David W. Fry,
James M. Nelson,
Veronika Slintak,
William L. Elliot,
Billy J. Roberts,
Patrick W. Vincent, and
Sandra J. Patmore
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1816-1822
| Synthesis, Mode of Action, and Biological Activities of Rebeccamycin Bromo Derivatives
Pascale Moreau,
Fabrice Anizon,
Martine Sancelme,
Michelle Prudhomme,
Danièle Sevère,
Jean-François Riou,
Jean-François Goossens,
Jean-Pierre Hénichart,
Christian Bailly,
Emmanuel Labourier,
Jamal Tazzi,
Doriano Fabbro,
Thomas Meyer, and
A. M. Aubertin
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1823-1827
| A New Method for Rapidly Generating Inhibitors of Glyoxalase I inside Tumor Cells Using S-(N-Aryl-N-hydroxycarbamoyl)ethylsulfoxides
Diana S. Hamilton,
Malcolm J. Kavarana,
Ellyn M. Sharkey,
Julie L. Eiseman, and
Donald J. Creighton
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1828-1835
| Studies on the Monoamine Oxidase-B-Catalyzed Biotransformation of 4-Azaaryl-1-methyl-1,2,3,6-tetrahydropyridine Derivatives
Sandeep K. Nimkar,
Stéphane Mabic,
Andrea H. Anderson,
Sonya L. Palmer,
Thomas H. Graham,
Milly de Jonge,
Lisa Hazelwood,
Sean J. Hislop, and
Neal Castagnoli, Jr.
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1836-1841
| Syntheses of Biotinylated  -Galactosylceramides and Their Effects on the Immune System and CD1 Molecules
Teruyuki Sakai,
Olga V. Naidenko,
Hirosi Iijima,
Mitchell Kronenberg, and
Yasuhiko Koezuka
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BRIEF ARTICLES
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1842-1848
| Synthesis and Evaluation of New Sulfur-Containing L-Arginine-Derived Inhibitors of Nitric Oxide Synthase
Kohji Ichimori and
Dennis J. Stuehr
, Robert N. Atkinson and
S. Bruce King
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1849-1854
| 3-Amino-5-phenoxythiophenes: Syntheses and Structure-Function Studies of a Novel Class of Inhibitors of Cellular L-Triiodothyronine Uptake
Detlef Briel,
Dirk Pohlers,
Mathias Uhlig,
Silke Vieweg,
Gerhard H. Scholz,
Michael Thormann, and
Hans-Jörg Hofmann
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1855-1861
| Synthesis of Novel Phenserine-Based-Selective Inhibitors of Butyrylcholinesterase for Alzheimer's Disease
Qian-sheng Yu,
Harold W. Holloway,
Tadanobu Utsuki,
Arnold Brossi, and
Nigel H. Greig
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BOOK REVIEWS
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1862-1862
| Smith and Williams' Introduction to the Principles of Drug Design and Action, 3rd Edition Edited by H. John Smith. Harwood Academic Publishers, Amsterdam. 1998. xiii + 454 pp. 17 x 25 cm. ISBN 90-5702-205-2. $30.00 (paperback) and $80.00 (cloth).
Robert D. Sindelar
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